Recent publications

Luquez T*, Algoo* J, Chiu R, Mares JA, Yadav A, Lam M, Gaur P, Lai X, Lee DI, Paryani F, Batchelor R, Belli I, Henry J, Hoter-Ishay B, Mattison C, Starr L, Lama T, Karaahmet B, Cao W, De Jager PL, Taga M, Barnes LL, Marquez DX, Bennett DA, Zhang Y, Menon V (2026) “Cell-type signatures of Alzheimer’s disease shared across population groups” Nature 650(8183):640-49.

Sloan NX*, Mares JA*, Daly AC*, Grier S, Haq I, Jackson CA, Barretto N, Casel O, Kang K, Khiste S, Harris K, Eschbach J, Fullerton BT, Mattison C, Gebremedhin B, Petrescu J, Cole L, Pedersen MH, Zhang K, Shu J, Teich AF, Reddy H, Smith CP, Suh Y, Menon V*, Phatnani* (2026) “Uncovering the signatures of aging and senescence in the human dorsolateral prefrontal cortex” Cell Genomics 6(2):101127.

Gaur P*, Bryois J*, Calini D*, Foo LC, Hoozemans JJM, Yadav A, Malhotra D*, Menon V* (2025) “Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology” Nature Communications 16(1):10395.

Green GS, Fujita M, Yang HS, Taga M, Cain A, McCabe C, Comandante-Lou N, White CC, Schmidtner AK, Zeng L, Sigalov A, Wang Y, Regev A, Klein HU, Menon V*, Bennett DA*, Habib N*, De Jager PL* (2024) “Cellular communities reveal trajectories of brain ageing and Alzheimer’s disease” Nature 633(8030):634-45.

Paryani F, Kwon JS, Ng CW, Jakubiak K, Madden N, Ofori K, Tang A, Lu H, Xia S, Li J, Mahajan A, Davidson SM, Basile AO, McHugh C, Vonsattel JP, Hickman R, Zody MC, Housman DE, Goldman JE, Yoo AS, Menon V*, Al-Dalahmah O* (2024) “Multi-omic analysis of Huntington’s disease reveals a compensatory astrocyte state” Nature Communications 15(1):6742.

Mares J, Costa AP, Dartora WJ, Wartchow KM, Lazarian A, Bennett DA, Nuriel T, Menon V*, McIntire LBJ* (2024) “Brain and serum lipidomic profiles implicate Lands cycle acyl chain remodeling association with APOE e4 and mild cognitive impairment” Front Aging Neurosci (16):1419253.

Qu W, Lam M, McInvale JJ, Mares JA, Kwon S, Humala N, Mahajan A, Nguyen T, Jakubiak KA, Mun JY, Tedesco TG, Al-Dalahmah O, Hussaini SA, Sproul AA, Siegelin MD, De Jager PL, Canoll P, Menon V*, Hargus G* (2024) “Xenografted human iPSC-dervied neurons with the familial Alzheimer’s disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator” Acta Neuropathologica 147(1):107.

Chintamen S*, Gaur P*, Vo N, Bradshaw EM, Menon V, Kernie SG (2024) “Distinct microglial transcriptomic signatures within the hippocampus” PLoS One 19(1):e0296280.

Yadav A*, Matson KJE*, Lee D, Alkaslasi MR, Roome RB, Ward ME, Phatnani H, Le Pichon CE, Menon V*, Levine AJ* (2024) “A reproducible signature of cytoskeletal and ALS-related genes in human motoneurons” Neuron 111(23):3742-44.

Cain A, Taga M, McCabe C, Green GS, Hekselman I, White CC, Lee DI, Gaur P, Rozenblatt-Rosen O, Zhang F, Yeger-Lotem E, Bennett DA, Yang HS, Regev A, Menon V*, Habib N*, De Jager PL* (2023) “Multicellular communities are perturbed in the aging human brain and Alzheimer’s disease” Nature Neuroscience 26(7):1267-1280.

Yadav A*, Matson KJE*, Li L, Hua I, Petrescu J, Kang K, Alkaslasi MR, Lee DI, Hasan S, Galuta A, Dedek A, Ameri S, Parnell J, Alshardan MM, Qumqumji FA, Alhamad SM, Wang AP, Poulen G, Lonjon N, Vachiery-Lahaye F, Gaur P, Nalls MA, Yue AQ, Ward ME, Hildrebrand ME, Mery PF, Bourinet E, Bauchet L, Tsai EC, Phatnani H, Le Pichon CE, Menon V*, Levine AJ (2023) “A cellular taxnomy of the adult human spinal cord” Neuron 111(3):328-44.

Luquez T, Gaur P, Kosater IM, Lam M, Lee DI, Mares J, Paryani F, Yadav A, Menon V* (2022) “Cell type-specific changes identified by single-cell transcriptomics in Alzheimer’s disease” Genome Medicine 14(1):136.